Virtual Screening with Generative Topographic Maps: How Many Maps Are Required?
نویسندگان
چکیده
منابع مشابه
Relevance learning in generative topographic maps
The generative topographic map (GTM) provides a flexible statistical model for unsupervised data inspection and topographic mapping. However, it shares the property of most unsupervised tools that noise in the data cannot be recognized as such and, in consequence, is visualized in the map. The framework of relevance learning or learning metrics as introduced in [4, 6] offers an elegant way to s...
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In addition to a topographic map of the retina, mammalian visual cortex contains superimposed, orderly periodic maps of features such as orientation, eye dominance, direction of motion and spatial frequency. There is evidence that these maps are overlaid so as to ensure that all combinations of the different parameters are represented as uniformly as possible across visual space. However, it is...
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We call "natural" image any photograph of an outdoor or indoor scene taken by a standard camera. We discuss the physical generation process of natural images as a combination of occlusions, transparencies and contrast changes. This description ts to the phenomeno-logical description of Gaetano Kanizsa according to which visual perception tends to remain stable with respect to these basic operat...
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In all mammals, much of the neocortex consists of orderly representations or maps of receptor surfaces that are typically topographic at a global level, while being modular at the local level. These representations appear to emerge in development as a result of a few interacting factors, and different aspects of brain maps may be developmentally linked. As a result, evolutionary selection for s...
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ژورنال
عنوان ژورنال: Journal of Chemical Information and Modeling
سال: 2018
ISSN: 1549-9596,1549-960X
DOI: 10.1021/acs.jcim.8b00650